Report: H5N1 mutated rapidly in Indonesian cluster

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Report: H5N1 mutated rapidly in Indonesian cluster

first_imgJul 12, 2006 (CIDRAP News) – Genetic studies show that the H5N1 avian influenza virus mutated multiple times as it spread through an Indonesia family in May, but the significance of the changes is uncertain, according to a news report today in Nature.The journal, basing its report on confidential genetic sequence data, published a chart showing that a total of 32 mutations were identified in viruses collected from six patients in the family case cluster. Previous reports from the World Health Organization and other experts gave the impression that only a few mutations had been found.The case cluster in North Sumatra involved a 37-year-old woman who apparently contracted the virus from poultry and then passed it to six relatives before she died. One of those six, a 10-year-old boy, then passed the virus to his father. WHO officials said last month that a specific mutation found in the boy and his father marked the first laboratory confirmation of human-to-human transmission of the virus.On May 23, the WHO said genetic sequencing of two viruses from the case cluster had shown “no evidence of genetic reassortment with human or pig influenza viruses and no evidence of significant mutations.” A month later, at the end of an avian flu conference in Jakarta, WHO officials told reporters the virus had mutated slightly when it infected the 10-year-old boy, and the same mutation showed up in his father. The mutation didn’t make the virus more transmissible or virulent, officials said.The genetic data obtained by Nature came from a presentation by University of Hong Kong virologist Malik Peiris at a closed session of the Jakarta meeting in June, the article says.The magazine says that 21 mutations were identified in a virus from the father of the 10-year-old boy, involving seven of the virus’s eight genes, suggesting that the virus was evolving rapidly as it spread. In addition, from one to four mutations were found in viruses collected from five other patients.The story says one of the mutations confers resistance to the antiviral drug amantadine, a finding not reported by the WHO.However, the virus did not spread beyond the extended family, as the article notes. “Many of the genetic changes did not result in the use of different amino acids by the virus,” the story says. “And there were no amino-acid changes in key receptor binding sites known to affect pathogenicity and transmissibility.”According to the magazine, viruses from six of the eight cases in the cluster have been sequenced, but the WHO has not shared the findings, saying they belong to Indonesia. The data have been released only to a few researchers linked to the WHO and the US Centers for Diseases Control and Prevention, the story says.Virologists quoted by the journal asserted that the withholding of sequence data on H5N1 is hindering scientists’ understanding of the virus. But WHO staff member Paul Gully replied, according to the article, that the agency’s job is investigating outbreaks, not doing academic research, and that labs don’t have the time or resources to do “high-quality sequencing” during outbreaks.See also:May 23 WHO statement on genetic data from the case clusterhttp://www.who.int/csr/don/2006_05_23/en/index.htmlJun 23 CIDRAP News story “H5N1 mutation showed human transmission in Indonesia”last_img read more

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Brown happy to be back

first_img Brown was harshly given his marching orders in last weekend’s 2-0 defeat at the Britannia Stadium when his sliding tackle on Charlie Adam was deemed worthy of a straight red by referee Kevin Friend. Sunderland appealed against the decision, as well as the three-match ban that would have gone with it, and the Football Association duly confirmed that the sending-off had been overturned. Press Association “Everyone goes through spells when they find it hard,” the Scot said. “That’s tough, then you make a decision do you bring him off, or you don’t start him. But you’re doing it for the benefit of him as well. “He’ll come through it, honestly. You can never guarantee anybody anything. But, as a footballer, he’ll definitely come through it.” And fellow Villa forward Gabriel Agbonlahor has also backed Benteke to turn around his form sooner rather than later. “I’ve been through it before when I’ve played as a striker,” he said. “You go through these spells when you feel like everyone’s on your back, the goals don’t come. But Christian’s a quality player, he’s got a big, strong personality and the goals will come. “It’s down to us as a team to keep creating the chances for him.” Wes Brown was happy to be able to play his part in Sunderland’s goalless draw at Aston Villa having seen his controversial red card at Stoke rescinded upon appeal. That cleared the way for centre-back Brown to line up on Saturday at Villa Park, where he helped Sunderland keep a clean sheet and climb off the foot of the Barclays Premier League table with only their second away point of the season. Speaking about an eventful past 10 days, Brown said: “They looked at it and it has been rescinded so I’m all happy now and we can move on. “Obviously, I didn’t think it was a sending-off. I’ve watched it a few times now and I still think I won the ball and my two feet were on the floor. “But it was a decision and the referee has either not seen it or seen it late and we have to get on with it now.” Brown and central defensive partner John O’Shea kept Villa striker Christian Benteke quiet all afternoon as his goal drought stretched into a seventh successive game. Since returning from a month on the sidelines with a hip injury, the Belgium international has looked a shadow of the player who scored five goals in his first five games of this season to add to the 23 he bagged last term. An uninspiring performance against the Black Cats ended when Benteke was substituted before full-time, to a murmur of ironic cheers from the home faithful. But Villa boss Paul Lambert has backed his prized asset to come good. last_img read more

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Lacey S.T.E.M. Fair Explores the Future on May 4

first_imgFacebook350Tweet0Pin0Submitted by City of Lacey Parks & RecreationLaceys’ annual S.T.E.M. Fair always focuses on science, technology, and the future but the 2019 date will bring even more as May 4 ties in with Star Wars and May the 4th be with you!  “When we realized the date for this year’s event we immediately began working on adding some Star Wars to the event.” states Jeannette Sieler, Recreation Supervisor with the City of Lacey.  “Attendees will be able to visit with droids and other Star Wars characters, pose for pictures, and take a look at the inner workings of these droids built by the Pacific Northwest R2builders club.”  Also this year kids can explore the Mobile Ed STEAM Museum offering hands on activities that will allow all ages to learn while having fun, which is a major goal of the Lacey STEM Fair.  “The STEAM Museum is a national traveling exhibit, we were lucky that they were in the area during this event as it will be an exciting addition!” says Sieler, “They will be set up in the Hub at Lacey (next to Ricardo’s) since their displays needed to be indoors, their placement there will expand the event beyond Huntamer Park.” The Museum of Flight will also be at the event with their Robot Garage!S.T.E.M. Fair began in 2014, evolving out of the Lacey Alternative Energy Fair, an event that focused on the electric car rally with student builders and drivers.  As Alternative fuel and energy sources became more mainstream, it made sense to move forward with something else the students were working on, which was competitive robotics.  STEM learning is essential today and the Lacey S.T.E.M. Fair allows local area students a chance to showcase what there are learning and bringing in businesses that can share STEM careers. Middle school and high school students take the stage to demonstrate their programing and construction as they run their robots through their paces.  In addition, students also are at various booths around the event sharing one on one with the public their various STEM projects.This multifaceted event brings the community together to explore, share, and learn from all angles, applying, discovering, and playing with all things STEM, plus adding A for Arts.  The event runs 10:00 a.m. – 3:00 p.m. and is free to attend! Visit http://www.ci.lacey.wa.us/living-in-lacey/the-community/arts-and-events/stem-fairFor more info!Lacey S.T.E.M. FairSaturday, May 4, 10:00 a.m. – 3:00 p.m.FREEHuntamer Park, 618 Woodland Sq Lp SE, Laceylast_img read more

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THE GIRLINTHATSONG HITS THE RIGHT NOTE TO WIN GRADE II, $200,000 LA CANADA STAKES BY 4 ¼ LENGTHS; BEJARANO, HOLLENDORFER TEAM FOR WIN

first_imgARCADIA, Calif. (Jan. 17, 2015)–Thegirlinthatsong pounced on pacesetter Jojo Warrior a quarter mile from home and went on to win Saturday’s Grade II, $200,000 La Canada Stakes by 4 ¼ lengths under Rafael Bejarano as even money favorite Lexie Lou got up for second. Trained by Jerry Hollendorfer, Thegirlinthatsong bested a half dozen other 4-year-old fillies and covered 1 1/16 miles in 1:43.84.Idle since running second in the Zia Park Oaks on Nov. 26, the 4-year-old Texas-bred daughter of My Golden Song tried Santa Anita’s main track for the first time and registered her fifth win from 19 overall starts. Second behind 8-5 second choice Jojo Warrior through splits of 23.63, 47.13 and 1:11.66, Thegirlinthatsong got the mile in 1:36.99 en route to her biggest career win.“She’s been training well here and we were looking for a good effort from her,” said Hollendorfer. “I think Rafael wanted to stay back a little more than what I wanted him to. I asked him to stay as close as he could and be comfortable, so he did that, and that ended up working out well.”Off at 6-1, Thegirlinthatsong paid $15.00, $4.20 and $2.60. Owned by Gatto, Hollendorfer, and Tim and Peter Russo, she picked up $120,000 for the win, increasing her earnings to $407,695.“I thought Lexie Lou and Jojo Warrior would go to the lead so I expected to put my horse right behind Jojo Warrior after the break,” said Bejarano. “When we broke, my horse was real fresh…I just put us right behind and I had a beautiful trip. By the three eighths pole, I still felt I had a lot of horse and when I let her go in the stretch, she took off.”Ridden by Corey Nakatani, Lexie Lou, who came off a second place finish to likely Horse of the Year California Chrome in the Grade I Hollywood Derby at Del Mar, was just up for the place by a head over Jojo Warrior while never threatening for the win. She paid $2.80 and $2.20.“Not bad for her first time on dirt, not bad at all,” said Nakatani. “When Jojo Warrior kind of crossed over (going into the first turn) she got a little dirt in her face and she started to jump a little. I lost our position but for her first time on dirt, she showed her heart and she ran a big race. The farther the better with her.”Jojo Warrior, who was ridden by Martin Garcia and appeared to be running easily on the lead, finished 5 ¾ lengths clear of longshot Une Cherise and paid $2.60 to show.There is a Pick Six carryover into Sunday at Santa Anita of $104,326 and it’s expected Sunday’s total pool should exceed $500,000. First post time is at 12:30 p.m., admission gates open at 10:30 a.m. PICK SIX CARRYOVER OF $104,326 INTO SUNDAY, TOTAL POOL SHOULD EXCEED $500,000last_img read more

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